Cost Effectiveness of Cytotoxic and Targeted Therapy for Metastatic Breast Cancer
نویسندگان
چکیده
منابع مشابه
HER-2 testing and trastuzumab therapy for metastatic breast cancer: a cost-effectiveness analysis.
PURPOSE Trastuzumab therapy has been shown to benefit metastatic breast cancer patients whose tumors exhibit HER-2 protein overexpression or gene amplification. Several tests of varying accuracy and cost are available to identify candidates for trastuzumab. We estimated the cost-effectiveness of alternative HER-2 testing and trastuzumab treatment strategies. PATIENTS AND METHODS We performed ...
متن کاملOsteoclast-targeted therapy for metastatic prostate cancer
10.2217/14750708.5.1.63 © 20 Bone metastases and skeletal complications are major causes of morbidity in men with prostate cancer. Despite the osteoblastic appearance of bone metastases on imaging studies, patients with bone metastases have elevated markers of bone resorption, indicative of high osteoclast activity. Indeed, increased osteoclast activity is independently associated with higher r...
متن کاملTargeted Therapy of Breast Cancer.
improve the efficacy of antihormonal therapy and may overcome endocrine treatment resistance at least temporarily in many patients. However, the impressive array of possible treatment combinations and sequences warrants an enormous amount of further research to identify optimal treatment algorithms. Further research will also have to focus on the exploration and establishment of predictive fact...
متن کاملChemotherapy for Metastatic Breast Cancer - An Anachronism in the Era of Personalised and Targeted Oncological Therapy?
Based on the findings of modern molecular biology, breast cancer is nowadays considered to be a heterogeneous disease. This leads to the objective of an individualised, more patient-oriented therapy. A series of target molecules for this purpose has already been identified. The principle of targeted oncological therapy was realised decades ago with the introduction of endocrine therapy for pati...
متن کاملThe cytotoxic effect of memantine and its effect on cytoskeletal proteins expression in metastatic breast cancer cell line
Objective(s):Breast cancer is an important leading cause of death from cancer. Stathmin and tau proteins are regulators of cell motility, and their overexpression is associated with the progression and bad prognosis of breast cancer. Memantine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is the potential inhibitor of tau protein in neurons. This study determines the effect of memantine ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PharmacoEconomics
سال: 2010
ISSN: 1170-7690
DOI: 10.2165/11535560-000000000-00000